SOLVED: MDM2p53Active TetramersCell CycleFigure: MDM2 and p53 signaling in response to DNA damage controls cell cycle progressionThe p53 and MDM2 proteins are involved in the DNA damage response pathway (Figure 1). In the absence of DNA damage, MDM2 mediates the degradation of p53. In the presence of DNA damage, p53 is not broken down and forms active tetramers that stimulate the expression of genes that block cell cycle progression.Red blood cells are produced by the division and differentiatio
SOLVED: MDM2p53Active TetramersCell CycleFigure: MDM…
Feb 10, 2022
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The Role of p53 in Cancer
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55 viewsNov 10, 2021
VimeoMaja Divjak
p53 is the guardian of the genome. p53 knockout mice (-/-) are highly susceptible to formation of tumors. why? failure to detect or accurately repair DNA damage can lead to oncogenesis, particularly if the mutations are in genes controlling the cell cycle, metabolism, and/or apoptosis #biochem #molecularbiology #oncogenesis #p53 #biotok #premed
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