A clinical-stage oncology company developing targeted therapies that exploit DNA damage response (DDR) vulnerabilities in ...

Particle therapy, including proton and carbon ion radiotherapy, represents a major advancement in cancer treatment due to its ...

A new study published by Mayo Clinic researchers suggests that ovarian cancer cells quickly activate a survival response ...

Red arrows indicate the DNA repair pathways that are known to aid bacterial survival as persisters and gamblers in the presence of fluoroquinolones. Blue color arrow indicates downregulation, while ...

A new study in fruit flies describes how an animal’s gut reacts differently to beneficial microbes versus harmful pathogens. A pathway known for repairing damaged genetic material, called the ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a ...

Yuan He aims to understand how cells read and repair their genomes. His research encompasses two primary areas: transcription, in which genetic information is copied from DNA into messenger RNA, and ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among the most dangerous forms of DNA damage and immediately trigger the cell's ...