Antibodies play a vital role in the immune system by providing protection against foreign invaders, such as bacteria and viruses. Produced by B cells, antibodies are protein molecules that can be ...

Artificial intelligence (AI) is a broad field covering many different disciplines and it can also have many applications when it comes to antibody discovery. AI can help with designing antibodies and ...

The development of therapeutic antibodies requires several steps of molecular engineering that optimize different aspects of antibody binding, specificity, effector and recycling functions. This often ...

The immune system strikes a fine balance by identifying and neutralizing disease-causing agents while carefully avoiding destruction of healthy tissues and cells. Now, researchers from Japan have shed ...

Two of the studies show how to enhance this process—known as affinity maturation—to lay a foundation for developing more broadly protective vaccines and antibody-based biologic treatments. The other ...

Antibody affinity maturation enables adaptive immune responses to a wide range of pathogens. In some individuals broadly neutralizing antibodies develop to recognize rapidly mutating pathogens with ...

Antibodies are essential for immune defense and safeguarding against bacteria, viruses, and other foreign entities. Produced by B cells, these protein molecules offer the potential for treating ...

The authors found that Csk (a tyrosine kinase that attenuates B cell receptor signaling) is required for germinal center maintenance and efficient antibody maturation. Osaka, Japan – The immune system ...